Cost Effectiveness Analysis of A Vaccine To Prevent Herpes Zoster and Postherpetic Neuralgia in Italy.
نویسندگان
چکیده
Background. Herpes zoster (HZ), or shingles, is a painful disease that results from reactivation of the varicella zoster virus (VZV) which has remained latent in sensory ganglia following primary infection i.e. varicella (VZV), a virus commonly acquired in childhood (chickenpox) [1]. The most common complication is post-herpetic neuralgia (PHN), a severe pain that can persist for months [2]. HZ and PHN have a significant impact on patients’ quality of life and well-being. Beside the negative impact on patient’s quality of life, HZ and PHN also generate a notable economic burden to the National Healthcare Service. A way to prevent the disease onset is Zostavax, that significantly reduces the incidence of HZ by 51% and the incidence of PHN by 67% in adults 60 years of age or older [3].
منابع مشابه
Cost-effectiveness of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.
BACKGROUND A vaccine to prevent herpes zoster was recently approved by the United States Food and Drug Administration. We sought to determine the cost-effectiveness of this vaccine for different age groups. METHODS We constructed a cost-effectiveness model, based on the Shingles Prevention Study, to compare varicella zoster vaccination with usual care for healthy adults aged >60 years. Outcom...
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Vaccination against herpes zoster and postherpetic neuralgia in France: a cost-effectiveness analysis.
This study assesses the cost-effectiveness of vaccination against herpes zoster (HZ) and postherpetic neuralgia in France, using a published Markov model. The cost-effectiveness of vaccinating individuals aged from 65 years or between 70 and 79 years was evaluated over their lifetime, from a third-party payer perspective. French-specific data were combined with results from clinical studies and...
متن کاملVaccination against herpes zoster in developed countries
Although progress has been made in the treatment of herpes zoster (HZ) and postherpetic neuralgia (PHN), available therapeutic options are only partially effective. Given evidence that a live-attenuated varicella-zoster-virus vaccine is effective at reducing the incidence of HZ, PHN and the burden of illness, policymakers and clinicians are being asked to make recommendations regarding the use ...
متن کاملA vaccine to prevent herpes zoster and post-herpetic neuralgia in older adults.
BACKGROUND The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella-zoster virus (VZV). We tested the hypothesis that vaccination against VZV would decrease the incidence, severity, or both of herpes zoster and postherpetic neuralgia among older adults. METHODS We enrolled 38,546 a...
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عنوان ژورنال:
- Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
دوره 17 7 شماره
صفحات -
تاریخ انتشار 2014